Measurement integrity for clinical data

Know which patients move when your instruments change.

NakedSignal measures what an analyser, site or device change does to results at your clinical decision limits, and gives you a plan to manage the switch.

Talk to us See a sample report

Runs on your own machine. Patient rows never leave.

10,579
paired patient results analysed
34
method comparisons
12
published studies
14
study sites

Why it matters

Every instrument change moves patients. The question is which ones.

Your method comparison software can already give you the bias at each decision limit. The report adds who now sits on the other side of a treatment threshold, against what repeat testing alone would move.

24 of the 29 published comparisons on the chart sit above the dashed line, a description of the counts rather than a test.
In the CD4 sample, 535 results changed category against about 238 expected at a default repeat-test imprecision, not one measured in that study.
A re-test band removed 66% of the excess over that default expectation while repeating 15% of results.

Results moved across a decision limit

Public data

Each dot is one published method comparison: results that crossed a decision limit after the change, against the number repeat testing alone would move. 7 of the 29 dots use an imprecision the study measured (the larger of its two systems); the other 22 use a default, which can be too high or too low. A dot above the dashed line is a description, not a test. Only the ringed creatinine study has the exact test at its measured 1.8% imprecision: 23 crossed against about 12 expected, probability 0.00017.

Chemistry Haematology and immunology At or below the dashed lineOpen the explorer

How it works

From the data you already have to a go-live plan.

Built on ISO 15189:2022 comparability of results and CLSI EP09 method comparison.

Export your paired results
The paired results from your method comparison or parallel testing. No new samples, no new study.
Measure at your decision limits
Bias where your clinicians act, and which patients cross each limit, set beside what repeat testing alone would move.
Manage the switch
A re-test band for the transition and a one-page note for requesting clinicians, ready for go-live.

Runs inside your laboratory

The analysis runs on your own computer. Patient rows never leave; only aggregate results do, and you sign off what is released.

Security

The change report

What a change report contains.

Open the sample report

Comparison line
How the new system relates to the old across your whole range, with its interval.
Bias at your limits
The difference at the concentrations where your clinicians act, not an average.
Patients across each limit
Who changed category, in each direction, set beside the count repeat testing alone would move.
Re-test band
A narrow range around each limit where results are repeated during the transition.
Clinician note
One page for requesting clinicians: what changed and what it means for their patients.
Network view
Across sites: which ones report interchangeably and which move patients.