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Evidence

Analyser change explorer

Public dataPublic method-comparison deposits, not a laboratory's data. Repeat-test imprecision is assumed unless marked measured.

34 method comparisons at 14 stand-in sites, from 12 open-access studies; each data set plays the part of one laboratory. Pick one to see the comparison line, the bias at its decision limits and how many results crossed a limit compared with repeat testing alone.

run 25 September 2026 · config 6eb23df45893 · run file sha256 5586cd892ef1

10,579 paired results in all. Of the 34 method comparisons, 21 get a full re-test band and 5 an indicative one, because they have fewer pairs than the minimum we set; the other 8 are shown as a comparison only or are too small for a band. In 6 comparisons the change moved fewer results across a limit than repeat testing alone would, and the explorer says so where it happens.

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Use the arrow keys to move through the comparisons.

    • Flow cytometry, laboratory platform to Point of care CD4 and haemoglobin analysercells/µL · 247 pairs · full band
    • Flow cytometry platform A (predicate) to Flow cytometry platform B (new)cells/µL · 205 pairs · full band · data set 1
    • Flow cytometry platform A (predicate) to Flow cytometry platform B (new)cells/µL · 1,885 pairs · full band · data set 2 · the sample report
    • Central lab serum analyser, kinetic Jaffe to Point of care analyser, venous whole bloodmg/dL · 89 pairs · indicative band
    • Central lab serum analyser, kinetic Jaffe to Point of care creatinine meter, capillarymg/dL · 89 pairs · indicative band
    • Central lab chemistry analyser to Point of care device Bmg/dL · 345 pairs · full band
    • Central lab analyser, Jaffe creatinine to Point of care creatinine meterµmol/L · 358 pairs · full band
    • Central lab analyser, enzymatic creatinine to Same analyser, kinetic Jaffe creatininemg/dL · 529 pairs · full band
    • Central lab haematology analyser to Point of care haematology analyser% · 201 pairs · comparison only
    • Central lab haematology analyser to Point of care CD4 and haemoglobin analyserg/dL · 128 pairs · full band
    • Central lab haematology analyser to Point of care haematology analyserg/dL · 201 pairs · full band
    • Laboratory haematology analyser (reference) to Point of care haemoglobin meter Ag/dL · 60 pairs · indicative band · central laboratory setting
    • Laboratory haematology analyser (reference) to Point of care haemoglobin meter Bg/dL · 56 pairs · indicative band · central laboratory setting
    • Laboratory haematology analyser (reference) to Point of care haemoglobin meter Cg/dL · 59 pairs · indicative band · central laboratory setting
    • Laboratory haematology analyser (reference) to Point of care haemoglobin meter Ag/dL · 100 pairs · full band · community clinic setting
    • Laboratory haematology analyser (reference) to Point of care haemoglobin meter Bg/dL · 100 pairs · full band · community clinic setting
    • Laboratory haematology analyser (reference) to Point of care haemoglobin meter Cg/dL · 100 pairs · full band · community clinic setting
    • Central lab chemistry analyser to Point of care device A% · 352 pairs · full band
    • Central lab chemistry analyser to Point of care device B% · 352 pairs · full band
    • Reference laboratory HbA1c method to Smartphone-read point of care HbA1c, capillarymmol/mol · 431 pairs · full band
    • Reference laboratory HbA1c method to Smartphone-read point of care HbA1c, venousmmol/mol · 246 pairs · full band
    • Laboratory HbA1c assay to Point of care HbA1c analyser% · 108 pairs · full band
    • Central lab analyser, directly measured LDL cholesterol to LDL cholesterol calculated by the Friedewald equationmg/dL (from mmol/L x 38.67) · 1,298 pairs · comparison only
    • Central lab analyser, directly measured LDL cholesterol to LDL cholesterol calculated by the Martin-Hopkins equationmg/dL (from mmol/L x 38.67) · 1,301 pairs · comparison only
    • Central lab haematology analyser to Point of care haematology analyserfL · 201 pairs · full band
    • Central lab haematology analyser to Point of care haematology analyser×10⁹/L · 197 pairs · comparison only
    • Haematology analyser A, impedance platelet count to Haematology analyser B, impedance platelet count×10⁹/L · 21 pairs · comparison only
    • Haematology analyser A, fluorescent platelet count to Haematology analyser B, optical platelet count×10⁹/L · 21 pairs · comparison only
    • Haematology analyser A, pre-diluted fluorescent platelet count to Haematology analyser B, pre-diluted optical platelet count×10⁹/L · 21 pairs · comparison only
    • Central lab haematology analyser to Point of care haematology analyser×10⁹/L · 199 pairs · full band
    • Central lab haematology analyser to Point of care haematology analyser×10¹²/L · 201 pairs · comparison only
    • Central lab chemistry analyser to Point of care device Amg/dL · 329 pairs · full band
    • Central lab chemistry analyser to Point of care device Bmg/dL · 352 pairs · full band
    • Central lab haematology analyser to Point of care haematology analyser×10⁹/L · 197 pairs · full band

Haematology and immunology

CD4 absolute count, cells/µL

Flow cytometry platform A (predicate) replaced by Flow cytometry platform B (new) (data set 2). 1,885 paired results.

This comparison on its own page

Comparison line

The new system reads 14.3% lower than the old system on average. The comparison line has a slope of 0.867 (95% interval 0.856 to 0.877) and an intercept of -1.2.

Public data
Comparison line, CD4 absolute count (cells/µL)Comparison line with slope 0.867 (95% interval 0.856 to 0.877) and intercept -1.2, drawn against the line of no change. Decision limits drawn at 100, 200, 350, 500 cells/µL. Where the comparison line sits above the line of no change, the new system reads higher; below, lower.200400600200400600100200350500No changeComparison lineOld system, cells/µLNew system, cells/µL

Fig. 1. The comparison line against the line of no change, over the range of the decision limits (100, 200, 350, 500 cells/µL). Dots mark where each line meets each limit; the gap between them is the bias at that limit.

run 25 September 2026 · config 6eb23df45893 · run file sha256 5586cd892ef1

Crossing each limit

Results that moved across a decision limit when the new system replaced the old, against the number repeat testing on one unchanged system would move. The program reports the count across all limits together.

All decision limits together (100, 200, 350, 500 cells/µL)

Crossed after the change: 535

Expected from repeat testing alone: about 238

Grade and warnings

  • Re-test band: full (at least the protocol minimum of pairs).
  • Band half-width around each limit: 5.51%.
  • Results re-tested on data the band was not fitted to, median: 15%.
  • Share of the excess crossings caught on unseen data, comparison line and band together: 66%; comparison line alone: 46%. The excess is the crossings above what repeat testing alone would cause, so the share can exceed 100% or fall below zero.
  • Repeat-test imprecision: assumed, not measured at this site.

Source

Coetzee LM, Glencross DK (2017). PLoS One. doi:10.1371/journal.pone.0187456 (opens in a new tab); PMC5669480 (opens in a new tab) (title on the source page; it names the instruments). Licence: CC BY 4.0 (opens in a new tab). Changes: Paired results re-analysed by NakedSignal's program; instruments described generically; only derived results are shown. The deposit names the systems.

Show the numbers
All values for CD4 absolute count, Flow cytometry platform A (predicate) to Flow cytometry platform B (new)
FieldValue
Paired results used1,885
Comparison line slope0.866667
Slope, 95% interval0.856122 to 0.877053
Comparison line intercept-1.2
Mean difference, new minus old, as % of old-14.284
Decision limits (cells/µL)100, 200, 350, 500
Crossed after the change535
Expected from repeat testing alone238.49
Band half-width (%)5.51
Re-tested, unseen data, median (%)15.01
Re-tested, unseen data, range (%)14.8 to 15.07
Excess caught, line and band (%)66.23
Excess caught, line alone (%)45.53

Each comparison on its own page

Every comparison above also has a page of its own, with its figure, every number the program wrote and the full citation of its study, so it can be linked and cited.

CD4 absolute count

creatinine

haematocrit

haemoglobin

HbA1c

LDL cholesterol

mean cell volume

neutrophil count

platelet count

red cell count

total cholesterol

white cell count

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